Esters of Methanesulfonic Acid as Irreversible Inhibitors of Acetylcholinesterase

Design and synthesis of new esters of terpenoid alcohols as 15-lipoxygenase inhibitors

Objective(s): 15-Lipoxygenases are one of the iron-containing proteins capable of performing peroxidation of unsaturated fatty acids in animals and plants. The critical role of enzymes in the formation of inflammations, sensitivities, and some cancers has been demonstrated in mammals. The importance of enzymes has led to the development of mechanistic studies, product analysis, and synthesis of ...

Suicide Substrates as Irreversible Inhibitors of Aavoenzymes

SUMMARY An increasing number of flavin dependent enzymes have recently been found to be inhibited by substrate analogs which fulfill the requirements set forth for suicide inhibitors. In most cases in-activation results from covalent modification of the flavin coenzyme; in other cases protein alkylation at the enzyme active center is involved. Examples of the first are the inactivation of gener...

novel coumarin analogues: as new acetylcholinesterase inhibitors

new pantacyclic tacrines as potent acetylcholinesterase inhibitors

Isolation and characterization of acetylcholinesterase inhibitors from Piper longum L.

Background and objectives: The cholinergic deficit correlates with the severity of Alzheimer’s disease. The cholinergic function can be improved by AChE inhibitors blocking this key enzyme in the breakdown of acetylcholine. Based on traditional medicine, during two last decades the use of herbal medicinal substances in dementia therapy has been studied. The fruit extract of <em...